Faculty Research 1990 - 1999

Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors.

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Animals-Wild, Antigen-Presentation, Disease-Susceptibility, Membrane-Glycoproteins, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-Strains, Papovaviridae-Infections, Polyomavirus, SUPPORT-U-S-GOVT-P-H-S, Tumor-Virus-Infections

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J Virol 1999 Dec; 73(12):10079-85.




Polyomavirus induces a broad array of tumors when introduced into newborn mice of certain standard inbred strains, notably those bearing the H-2(k) haplotype. Susceptibility in these mice is conferred by an endogenous mouse mammary tumor virus superantigen (Mtv-7 sag) that acts to delete T cells required for polyomavirus-induced tumor immunosurveillance. In the present study we show that mice of two wild-derived inbred strains, PERA/Ei (PE) and CZECH II/Ei (CZ), are highly susceptible to polyomavirus but carry no detectable Mtv sag-related sequences and show no evidence of Vbeta deletion. C57BR/cdJ (BR) mice, which are H-2(k) but lack the endogenous Mtv-7, are highly resistant based on an effective anti-polyomavirus tumor immune response. When crossed with BR, both PE and CZ mice transmit their susceptibility in a dominant fashion, indicating a mechanism(s) that overrides the immune response of BR. Susceptibility in PE and CZ mice is not based on interference with antigen processing or presentation since cytotoxic T cells from BR can efficiently kill F(1)-derived tumor cells in vitro. The expected precursors of polyomavirus-specific cytotoxic T cells are present in both the wild inbred animals and their F(1) progeny. These findings indicate a novel basis of susceptibility that operates independently of endogenous superantigen and prevents the development of tumor immunity.

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