Faculty Research 1990 - 1999
Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled.
Document Type
Article
Publication Date
1999
Keywords
Animal, Cadherins, Cell-Adhesion, Cell-Polarity, Cells-Cultured, Conserved-Sequence, Cytoskeleton, Drosophila, Gene-Expression-Regulation-Developmental, Membrane-Proteins, Mice, Models-Biological, Molecular-Sequence-Data, Mutagenesis, Sequence-Homology-Amino-Acid, SUPPORT-NON-U-S-GOVT, Time-Factors, Transfection, Wing
First Page
585
Last Page
595
JAX Source
Cell 1999 Sep; 98(5):585-95.
Abstract
We identified a seven-pass transmembrane receptor of the cadherin superfamily, designated Flamingo (Fmi), localized at cell-cell boundaries in the Drosophila wing. In the absence of Fmi, planar polarity was distorted. Before morphological polarization of wing cells along the proximal-distal (P-D) axis, Fmi was redistributed predominantly to proximal and distal cell edges. This biased localization of Fmi appears to be driven by an imbalance of the activity of Frizzled (Fz) across the proximal/distal cell boundary. These results, together with phenotypes caused by ectopic expression of fz and fmi, suggest that cells acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi.
Recommended Citation
Usui T,
Shima Y,
Shimada Y,
Hirano S,
Burgess RW,
Schwarz TL,
Takeichi M,
Uemura T.
Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 1999 Sep; 98(5):585-95.