Faculty Research 1990 - 1999
The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12.
Document Type
Article
Publication Date
1991
Keywords
Chromosome-Mapping, Crosses-Genetic, Female, Kidney-Polycystic: ge, Linkage-(Genetics), Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Translocation-(Genetics)
First Page
778
Last Page
781
JAX Source
Genomics 1991 Apr;9(4):778-81
Grant
RR01183, GM32105
Abstract
The mouse congenital polycystic kidney (cpk) mutation produces a condition that resembles human autosomal recessive polycystic kidney disease (ARPKD) in its pattern of inheritance, clinical progression, and histopathology. Inheritance of this mouse mutation in crosses segregating the Rb(12.14)8Rma translocation chromosome and various DNA markers of Chromosome 12 have localized cpk to a site near D12Nyu2, approximately 7 cM from the centromere of Chromosome 12. This result suggests that the homologous PKD2 gene should be localized to either human chromosome 2p23-p25 or chromosome 7q22-q31.
Recommended Citation
Davisson MT,
Guay WL,
Harris HW,
D'Eustachio P.
The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12. Genomics 1991 Apr;9(4):778-81