Faculty Research 1990 - 1999
Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
Document Type
Article
Publication Date
1992
Keywords
Animal, Blotting-Southern, Chromosome-Deletion, Crosses-Genetic, DNA: ge, Eye-Color: ge, Female, Genes-Recessive, Genotype, Male, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
6968
Last Page
6972
JAX Source
Proc Natl Acad Sci U S A 1992 Aug 1;89(15):6968-72
Grant
GM20919, CA09217, GM43840
Abstract
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
Recommended Citation
Lyon MF,
King TR,
Gondo Y,
Gardner JM,
Nakatsu Y,
Eicher EM,
Brilliant MH.
Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc Natl Acad Sci U S A 1992 Aug 1;89(15):6968-72