Faculty Research 1990 - 1999


Geographic origin of the Y chromosomes in "old: inbred strains of mice.

Document Type


Publication Date



Asia, Base-Sequence, DNA-Viral, Europe, Female, Male, Mice, Mice-Inbred-Strains: ge, Molecular-Probes, Molecular-Sequence-Data, Muridae: ge, Open-Reading-Frames, Restriction-Fragment-Length-Polymorphisms, Species-Specificity, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Y-Chromosome

JAX Source

Mamm Genome 1992;3(5):254-61


GM20919, HD07065


Six distinct Y Chromosomes (Chr) were identified among 39 standard inbred strains of mice with five probes that identified Y Chr-specific restriction fragments on Southern blots. Three Y Chr types, distributed among 31 strains, were of Asian Mus musculus origin. The remaining three Y Chr types, distributed among eight strains, were of M. domesticus origin. The Asian source of the M. musculus Y Chr was confirmed by determining the DNA sequence of 221 bp from an open reading frame within the Sry (sex determining region Y) gene (Gubbay et al., Nature 346: 245-250, 1990) in three inbred strains (C57BL/6J, AKR/J, and SWR/J) and comparing the sequence to the homologous sequences derived from wild caught European and Asian M. musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains.

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