Faculty Research 1990 - 1999
The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes.
Document Type
Article
Publication Date
1992
Keywords
Amino-Acid-Sequence, Animal, Base-Sequence, Comparative-Study, Drosophila-melanogaster: ge, DNA: ge, Enhancer-Elements-(Genetics), Fetal-Development: ge, Genes-Structural, Genetic-Techniques, Mice: em, ge, Molecular-Sequence-Data, Open-Reading-Frames, Organ-Specificity, Proteins: bi, ge, Recombinant-Fusion-Proteins: bi, ge, RNA-Messenger: an, Saccharomyces-cerevisiae: ge, Sequence-Alignment, Sequence-Homology-Amino-Acid, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Transcription-Factors: bi, ge
First Page
111
Last Page
123
JAX Source
Mech Dev 1992 Nov;39(1-2):111-23
Grant
5R01HD2533403/HD/NICHD
Abstract
A novel mouse gene, Enhancer trap locus 1 (Etl-1), was identified in close proximity to a lacZ enhancer trap integration in the mouse genome showing a specific beta-galactosidase staining pattern during development. In situ analysis revealed a widespread but not ubiquitous expression of Etl-1 throughout development with particularly high levels in the central nervous system and epithelial cells. The amino acid sequence of the Etl-1 protein deduced from the cDNA shows strong similarity, over a stretch of 500 amino acids, to the Drosophila brahma protein involved in the regulation of homeotic genes and to the yeast transcriptional activator protein SNF2/SWI2 as well as to the RAD54 protein and the recently described helicase-related yeast proteins STH1 and MOT1. Etl-1 is the first mammalian member of this group of proteins that are implicated in gene regulation and/or influencing chromatin structure. The homology to the regulatory proteins SNF2/SWI2 and brahma and the expression pattern during embryogenesis suggest that Etl-1 protein might be involved in gene regulating pathways during mouse development.
Recommended Citation
Soininen R,
Schoor M,
Henseling U,
Tepe C,
Kisters WB,
Rossant J,
Gossler A.
The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes. Mech Dev 1992 Nov;39(1-2):111-23