Faculty Research 1990 - 1999
Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa.
Document Type
Article
Publication Date
1993
Keywords
Cell-Compartmentation, Fluorescent-Antibody-Technique, Human, Male, Phosphorylation, Protein-Tyrosine-Kinase: me, Receptors-Epidermal-Growth-Factor-Urogastrone: me, Spermatozoa: me, ul, SUPPORT-U-S-GOVT-P-H-S
First Page
901
Last Page
906
JAX Source
Biochem Biophys Res Commun 1993 Feb 15;190(3):901-6
Grant
HD21355/HD/NICHD, CA10815/CA/NCI
Abstract
The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [gamma-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization.
Recommended Citation
Damjanov I,
Solter D,
Knowles BB.
Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa. Biochem Biophys Res Commun 1993 Feb 15;190(3):901-6