Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa.
Cell-Compartmentation, Fluorescent-Antibody-Technique, Human, Male, Phosphorylation, Protein-Tyrosine-Kinase: me, Receptors-Epidermal-Growth-Factor-Urogastrone: me, Spermatozoa: me, ul, SUPPORT-U-S-GOVT-P-H-S
Biochem Biophys Res Commun 1993 Feb 15;190(3):901-6
The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [gamma-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization.
Damjanov, I; Solter, D; and Knowles, B B., " Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa." (1993). Faculty Research 1990 - 1999. 365.