Faculty Research 1990 - 1999

Fine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a candidate gene for Danforth's short tail (Sd).

Document Type


Publication Date



Chromosome-Mapping, Crosses-Genetic, Female, Male, Mice, Mice-Inbred-C57BL, Mutation, Spinal-Cord: ab, SUPPORT-NON-U-S-GOVT, Tail, Urogenital-System: ab

First Page


Last Page


JAX Source

Mamm Genome 1993;4(6):324-7


Danforth's short tail (Sd) is a semidominant mutation of the mouse with effects on the skeleton and the urogenital system. In view of its phenotype and its position in the proximal part of Chromosome (Chr) 2, three genes qualified as possible candidates: Pax-8, a paired box-containing gene; Midkine (Mdk), a retinoic acid-responsive gene; and a new locus (Etl-4) identified by enhancer trapping with a lacZ reporter gene which showed expression in the notochord, the mesonephric mesenchyme, and the apical ectodermal ridge. Three different backcrosses involving all three genes in different combinations were set up and analyzed. From our results we conclude that Sd, Etl-4, Pax-8, and Mdk are independent loci, with Etl-4 being the closest genetic marker (1.1 +/- 1.4 cM) to the Danforth's short tail (Sd) gene.

Please contact the Joan Staats Library for information regarding this document.