Faculty Research 1990 - 1999
The stumbler mutation maps to proximal mouse chromosome 2.
Document Type
Article
Publication Date
1994
Keywords
Base-Sequence, Cerebellar-Ataxia: ge, Chromosome-Mapping, Crosses-Genetic, Female, Genetic-Markers, Male, Mice: ge, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Neurologic-Mutants, Molecular-Sequence-Data, Mutation, Polymerase-Chain-Reaction, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S
First Page
659
Last Page
662
JAX Source
Mamm Genome 1994 Nov;5(11):659-62
Grant
R01NS31348/NS/NINDS, U01HD28882/HD/NICHD, CA34196/CA/NCI
Abstract
The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.
Recommended Citation
Frankel WN,
Sweet HO,
Davisson MT.
The stumbler mutation maps to proximal mouse chromosome 2. Mamm Genome 1994 Nov;5(11):659-62