Faculty Research 1990 - 1999
Taking stock of complex trait genetics in mice.
Document Type
Article
Publication Date
1995
Keywords
Crosses-Genetic, Hereditary-Diseases: ge, Human, Major-Histocompatibility-Complex, Mice: ge, Mice-Inbred-Strains: ge, Models-Genetic, Phenotype, SUPPORT-NON-U-S-GOVT
First Page
471
Last Page
477
JAX Source
Trends Genet 1995 Dec;11(12):471-7
Abstract
The mapping of complex trait loci in mice has recently become very popular thanks to dense genetic maps, better approaches to linkage analysis and the continued value of the mouse as a key model organism for human disease. Nevertheless, the ultimate goal remains very difficult to identify genes that underlie complex traits and to understand their function at a molecular level. In assessing the prospects of current efforts, it helps to review the findings of earlier studies of complex traits and, despite all the technology, to be reminded of the inherent benefits and limitations at the source of genetic variation: the laboratory mouse. With the right perspective it should be possible for geneticists analysing complex traits to take full advantage of the resources that the genome project will provide.
Recommended Citation
Frankel WN.
Taking stock of complex trait genetics in mice. Trends Genet 1995 Dec;11(12):471-7