Faculty Research 1990 - 1999
Title
Characterization of the mouse gene encoding phospholipid transfer protein.
Document Type
Article
Publication Date
1997
Keywords
Base-Sequence, Carrier-Proteins: ge, Cloning-Molecular, Gene-Expression-Regulation, Membrane-Proteins: ge, Mice, Molecular-Sequence-Data, Phospholipids: me, Promoter-Regions-(Genetics), SUPPORT-U-S-GOVT-P-H-S
First Page
115
Last Page
118
JAX Source
Gene 1997 Mar 25;188(1):115-8
Grant
HL30086/HL/NHLBI
Abstract
The mouse gene encoding phospholipid transfer protein (PLTP) was cloned from 129/SvJ lambdaFIX(R) II library and characterized for the first time. It is comprised of 16 exons separated by 15 introns. Its gene organization strikingly resembles that encoding the human PLTP; the exon-intron junctions in these two genes are completely conserved. Sequencing analysis reveals that the putative promoter of mouse PLTP gene consists of a TATA-box, a high GC region, and several consensus sequences for the binding of transcription factors. Within the first 200 bp of the 5'-flanking region, the mouse and human PLTP genes share 81.1% identity of nt sequences and contain the consensus sequences for the transcription factors AP-2 and Sp1 at the same locations.
Recommended Citation
Tu, A Y.; Chen, H; Johnson, K A.; Paigen, B; and Albers, J J., " Characterization of the mouse gene encoding phospholipid transfer protein." (1997). Faculty Research 1990 - 1999. 855.
https://mouseion.jax.org/stfb1990_1999/855