Faculty Research 1990 - 1999
Title
Characterization of the mouse gene encoding phospholipid transfer protein.
Document Type
Article
Publication Date
1997
Keywords
Base-Sequence, Carrier-Proteins: ge, Cloning-Molecular, Gene-Expression-Regulation, Membrane-Proteins: ge, Mice, Molecular-Sequence-Data, Phospholipids: me, Promoter-Regions-(Genetics), SUPPORT-U-S-GOVT-P-H-S
First Page
115
Last Page
118
JAX Source
Gene 1997 Mar 25;188(1):115-8
Grant
HL30086/HL/NHLBI
Abstract
The mouse gene encoding phospholipid transfer protein (PLTP) was cloned from 129/SvJ lambdaFIX(R) II library and characterized for the first time. It is comprised of 16 exons separated by 15 introns. Its gene organization strikingly resembles that encoding the human PLTP; the exon-intron junctions in these two genes are completely conserved. Sequencing analysis reveals that the putative promoter of mouse PLTP gene consists of a TATA-box, a high GC region, and several consensus sequences for the binding of transcription factors. Within the first 200 bp of the 5'-flanking region, the mouse and human PLTP genes share 81.1% identity of nt sequences and contain the consensus sequences for the transcription factors AP-2 and Sp1 at the same locations.
Recommended Citation
Tu AY,
Chen H,
Johnson KA,
Paigen B,
Albers JJ.
Characterization of the mouse gene encoding phospholipid transfer protein. Gene 1997 Mar 25;188(1):115-8