Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.
Document Type
Article
Publication Date
2005
Keywords
Animals, Antigens-CD27, Aorta, Apolipoproteins-E, Arteriosclerosis, Case-Control-Studies, Cholesterol-Dietary, Comparative-Study, Crosses-Genetic, Female, Genetic-Predisposition-to-Disease, Membrane-Glycoproteins, Mice-Inbred-BALB-C, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Knockout, Middle-Aged, Phenotype, Polymorphism-Single-Nucleotide, Quantitative-Trait-Loci
First Page
365
Last Page
372
JAX Source
Nat Genet 2005 Apr; 37(4):365-72.
Abstract
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P
Recommended Citation
Wang X,
Ria M,
Kelmenson PM,
Eriksson P,
Higgins DC,
Samnegard A,
Petros C,
Bennet AM,
Ishii N,
Hamsten A,
Forsman SK,
Lagercrantz J,
Paigen B,
Et al .
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 2005 Apr; 37(4):365-72.