Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens.

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Animal, Antigen-Presentation, Antigen-Presenting-Cells, Base-Sequence, Cell-Line, Comparative-Study, Cytotoxicity-Immunologic, Epitopes-T-Lymphocyte, H-2-Antigens, Lymphocyte-Transformation, Mice, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Minor-Histocompatibility-Antigens, Minor-Histocompatibility-Loci, Molecular-Sequence-Data, Oligopeptides, Protein-Binding, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic, Transcription-Genetic

JAX Source

Immunity 2000 Sep; 13(3):333-44.


Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.

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