Humanized mice: are we there yet?
Document Type
Article
Publication Date
2005
Keywords
Humans, Mice-Inbred-NOD, Mice-SCID, Mice-Transgenic, Models-Immunological
First Page
1307
Last Page
1311
JAX Source
J Exp Med 2005 Nov; 202(10):1307-11.
Abstract
Animal models have been instrumental in increasing the understanding of human physiology, particularly immunity. However, these animal models have been limited by practical considerations and genetic diversity. The creation of humanized mice that carry partial or complete human physiological systems may help overcome these obstacles. The National Institute of Allergy and Infectious Diseases convened a workshop on humanized mouse models for immunity in Bethesda, MD, on June 13-14, 2005, during which researchers discussed the benefits and limitations of existing animal models and offered insights into the development of future humanized mouse models.
Recommended Citation
Macchiarini F,
Manz MG,
Palucka AK,
Shultz LD.
Humanized mice: are we there yet? J Exp Med 2005 Nov; 202(10):1307-11.