Inferring network interactions within a cell.
Document Type
Article
Publication Date
2005
Keywords
Computer-Simulation, Gene-Expression-Profiling, Gene-Expression-Regulation-Fungal, Models-Biological, Protein-Array-Analysis, Protein-Interaction-Mapping, Saccharomyces-cerevisiae, Saccharomyces-cerevisiae-Proteins, Signal-Transduction
First Page
380
Last Page
389
JAX Source
Brief Bioinform 2005 Dec; 6(4):380-9.
Abstract
The continuing growth in high-throughput data acquisition has led to a proliferation of network models to represent and analyse biological systems. These networks involve distinct interaction types detected by a combination of methods, ranging from directly observed physical interactions based in biochemistry to interactions inferred from phenotype measurements, genomic expression and comparative genomics. The discovery of interactions increasingly requires a blend of experimental and computational methods. Considering yeast as a model system, recent analytical methods are reviewed here and specific aims are proposed to improve network interaction inference and facilitate predictive biological modelling.
Recommended Citation
Carter GW.
Inferring network interactions within a cell. Brief Bioinform 2005 Dec; 6(4):380-9.