EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.
Document Type
Article
Publication Date
2006
Keywords
Antioxidants, Apoptosis, Apoptosis-Inducing-Factor, Biomechanics, Blood-Pressure, Ethylenediamines, Fibrosis, Heart-Failure-Congestive, Mice, Mitochondria, Mutation, Myocardium, Necrosis, Organometallic-Compounds, Oxidative-Stress, Reactive-Oxygen-Species, Survival-Analysis
First Page
824
Last Page
832
JAX Location
see Reprint Collection
JAX Source
J Am Coll Cardiol 2006 Aug; 48(4):824-32.
Abstract
OBJECTIVES: The purpose of this study was to identify apoptosis-inducing factor (AIF) as a cardiac mitochondrial antioxidant and assess the efficacy of EUK-8, a salen-manganese catalytic free radical scavenger, to protect the AIF-deficient myocardium against pressure overload. BACKGROUND: Oxidative stress has been postulated to provoke cell death and pathologic remodeling in heart failure.
Recommended Citation
van EV,
Bertrand AT,
van OR,
van dN,
Engelen M,
van RH,
Doevendans PA,
Crijns HJ,
Ackerman SL,
Sluiter W,
De WL.
EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol 2006 Aug; 48(4):824-32.