TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Autoimmunity, Capsaicin, Diabetes-Mellitus-Type-1, Female, Inflammation, Insulin-Resistance, Insulin-Secreting-Cells, Islets-of-Langerhans, Male, Mice, Mice-Congenic, Mice-Inbred-C57BL, Mice-Inbred-NOD, Neurons-Afferent, Substance-P, T-Lymphocytes, TRPV-Cation-Channels
Cell 2006 Dec; 127(6):1123-35.
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1(+) pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and beta cell stress of prediabetic NOD mice are prevented when TRPV1(+) neurons are eliminated. TRPV1(NOD), localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1(-/-) mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1(+) sensory neurons in beta cell function and diabetes pathoetiology.
Razavi, R; Chan, Y; Afifiyan, F N.; Liu, X J.; Wan, X; Yantha, J; Tsui, H; Tang, L; Tsai, S; Santamaria, P; Driver, J P.; Serreze, D; Salter, M W.; and Dosch, H M., "TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes." (2006). Faculty Research 2000 - 2009. 1431.