Humanized mice in translational biomedical research.
Document Type
Article
Publication Date
2007
Keywords
Chimera, Communicable-Diseases, Disease-Models-Animal, Hematopoiesis, Humans, Mice-Knockout, Mice-SCID, Mice-Transgenic, Neoplasms
First Page
118
Last Page
130
JAX Source
Nat Rev Immunol 2007 Feb; 7(2):118-30.
Abstract
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
Recommended Citation
Shultz LD,
Ishikawa F,
Greiner DL.
Humanized mice in translational biomedical research. Nat Rev Immunol 2007 Feb; 7(2):118-30.