Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus).
Document Type
Article
Publication Date
2007
Keywords
Base-Sequence, DNA-Viral, Genome-Viral, Molecular-Sequence-Data, Muridae, Open-Reading-Frames, Papillomaviridae, Papillomavirus-Infections, Promoter-Regions-(Genetics), Viral-Proteins
First Page
1484
Last Page
1488
JAX Source
J Gen Virol 2007 May; 88(5):1484-8.
Abstract
The papillomaviruses form a large group of species-specific pathogens that cause epithelial proliferations in a wide spectrum of animal hosts. Previous reports demonstrated a relatively high frequency of a variety of skin lesions in captive European harvest mice. The Micromys minutus papillomavirus (MmPV) was isolated from one of these lesions found on a captive European harvest mouse in a regional zoo in Chicago. In this study we present the entire genomic sequence of MmPV. The MmPV genome is organized into the seven classical papillomaviral open reading frames. Phylogenetic analysis places MmPV together with a papillomavirus (PV) isolated from a Syrian golden Hamster (HaOPV) in the genus Pipapillomavirus. The similar clustering pattern of the MmPV-HaOPV pair and their rodent hosts support the hypothesis of papillomaviral and host co-phylogenetic descent. The availability of the complete genomic sequence of a mouse PV should allow researchers to use MmPV as a model for PV carcinogenesis.
Recommended Citation
Van DK,
Rector A,
Jenson AB,
Sundberg JP,
Van RM,
Ghim SJ.
Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus). J Gen Virol 2007 May; 88(5):1484-8.