Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice.
Disease-Models-Animal, Fimbriae-Bacterial, Genetic-Heterogeneity, Immunoglobulin-A, Immunoglobulin-G, Mice, Mice-Inbred-BALB-C, Porphyromonas-gingivalis, Species-Specificity, Specific-Pathogen-Free-Organisms, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Virulence
Oral Microbiol Immunol 2000 Feb; 15(1):27-32.
These experiments examine alveolar bone loss in a model in which specific pathogen-free mice are exposed orally with Porphyromonas gingivalis. Alveolar bone loss was induced as a result of a specific infection with P. gingivalis, rather than other environmental antigens. Infection with live P. gingivalis was required, as significant bone loss did not follow gavage with formalin-killed P. gingivalis. The virulence of different strains of P. gingivalis was compared. Two laboratory strains of the bacteria (ATCC 53977 and W50) and a mutant strain lacking the 43-kDa fimbrillin (strain DPG3) induced bone loss. P. gingivalis 381, however, did not induce bone loss. There was a strong immunoglobulin G (IgG) antibody response to infection with each strain but a significant serum IgA response only to strain 381. These studies show that in mice with a background oral microflora bone loss is induced by a specific infection with P. gingivalis and that bacterial strain variation is important in determining whether alveolar bone loss will ensue.
Baker, P J.; Dixon, M; Evans, R T.; and Roopenian, D C., " Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice." (2000). Faculty Research 2000 - 2009. 172.
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