Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14.
Document Type
Article
Publication Date
2008
Keywords
Cataract, Human-papillomavirus-18, Humans, Immunohistochemistry, Keratin-14, Mice-Transgenic, Oncogene-Proteins-Viral, Promoter-Regions-(Genetics), Transgenes
First Page
77
Last Page
82
JAX Location
see Reprint Collection (a pdf is available)
JAX Source
Exp Mol Pathol 2008 Oct; 85(2):77-82.
Abstract
Human papillomavirus type 18 (HPV18) is a common cause of cervical cancer. To create a mouse model for this common neoplastic disease, we used a human keratin 14 promoter to drive the HPV18 E7 oncogene to create transgenic mice. No mice up to a year of age developed cervical cancer. However, all transgenic mice and none of the controls developed progressive bilateral cortical cataracts. By 6 months of age, the cortex liquefied leaving the lens nucleus. Proliferation of lens epithelium formed multifocal nodules and free floating lens epithelial cells within the liquefied cortex. These cells were hyperplastic not neoplastic. Other HPV transgenic stocks develop cataracts suggesting this virus may have a broad cellular tropism.
Recommended Citation
Ghim S,
Jenson AB,
Bubier JA,
Silva KA,
Smith RS,
Sundberg JP.
Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14. Exp Mol Pathol 2008 Oct; 85(2):77-82.