Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Artemisinins, Chloroquine, Disease-Models-Animal, Erythrocytes, Humans, Interleukin-Receptor-Common-gamma-Subunit, Kinetics, Malaria-Falciparum, Mice-Inbred-NOD, Mice-SCID, Pyridones, Pyrimethamine
see Reprint Collection (a pdf is available)
Antimicrob Agents Chemother 2009 Oct; 53(10):4533-6.
Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.
Jimenez, Diaz M.; Mulet, T; Viera, S; Gomez, V; Garuti, H; Ibanez, J; Alvarez, Doval A.; Shultz, L D.; Martinez, A; Gargallo, Viola D.; and Angulo, Barturen I., "Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes." (2009). Faculty Research 2000 - 2009. 2045.