Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice.
Document Type
Article
Publication Date
2001
Keywords
Crosses-Genetic, Disease-Models-Animal, Female, Gene-Rearrangement, Gene-Rearrangement-beta-Chain-T-Cell-Antigen-Receptor, Genes-T-Cell-Receptor-beta, Immunoglobulins-Heavy-Chain, Immunoglobulins-kappa-Chain, Lymphoma-Large-Cell, Lymphoma-Lymphoblastic, Lymphoma-Non-Hodgkin, Mice-Inbred-AKR, Mice-Inbred-DBA, Mice-Knockout
First Page
719
Last Page
733
JAX Location
see Reprint Collection.
JAX Source
Leuk Res 2001 Aug; 25(8):719-33
Grant
CA33093/CA/NCI
Abstract
Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V(+) and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.
Recommended Citation
Morse HC,
Qi CF,
Hori M,
Taddesse HL,
Ozato K,
Taylor BA,
Ward JM,
Jenkins NA,
Copeland NG,
Fredrickson TN.
Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. Leuk Res 2001 Aug; 25(8):719-33