Crossover interference in the mouse.
Document Type
Article
Publication Date
2002
First Page
1123
Last Page
1131
JAX Source
Genetics 2002 Mar; 160(3):1123-1131.
Abstract
We present an analysis of crossover interference in the mouse genome, on the basis of high-density genotype data from two reciprocal interspecific backcrosses, comprising 188 meioses. Overwhelming evidence was found for strong positive crossover interference with average strength greater than that implied by the Carter-Falconer map function. There was some evidence for interchromosomal variation in the level of interference, with smaller chromosomes exhibiting stronger interference. We further compared the observed numbers of crossovers to previous cytological observations on the numbers of chiasmata and evaluated evidence for the obligate chiasma hypothesis.
Recommended Citation
Broman KW,
Rowe LB,
Churchill GA,
Paigen K.
Crossover interference in the mouse. Genetics 2002 Mar; 160(3):1123-1131.