A novel mechanism of resistance to mouse mammary tumor virus infection.


T V. Golovkina

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Animals-Newborn, B-Lymphocytes, Cells-Cultured, Chromosome-Mapping, CD4-Positive-T-Lymphocytes, DNA-Viral, Female, Genes-Recessive, Immunity-Natural, Male, Mammae, Mammary-Neoplasms-Experimental, Mice, Mice-Inbred-C3H, Mice-Neurologic-Mutants, Retroviridae-Infections, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Tumor-Virus-Infections, Virus-Shedding

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J Virol 2000 Mar; 74(6):2752-9.


CA65795/CA/NCI, CA34196/CA/NCI


Exogenous mouse mammary tumor virus (MMTV) is carried from the gut of suckling pups to the mammary glands by lymphocytes and induces mammary gland tumors. MMTV-induced tumor incidence in inbred mice of different strains ranges from 0 to as high as 100%. For example, mice of the C3H/HeN strain are highly susceptible, whereas mice of the I/LnJ strain are highly resistant. Of the different factors that together determine the susceptibility of mice to development of MMTV-induced mammary tumors, genetic elements play a major role, although very few genes that determine a susceptibility-resistance phenotype have been identified so far. Our data indicate that MMTV fails to infect mammary glands in I/LnJ mice foster nursed on viremic C3H/HeN females, even though the I/LnJ mammary tissue is not refractory to MMTV infection. Lymphocytes from fostered I/LnJ mice contained integrated MMTV proviruses and shed virus but failed to establish infection in the mammary glands of susceptible syngeneic (I x C3H.JK)F(1) females. Based on the susceptible-resistant phenotype distribution in N(2) females, both MMTV mammary gland infection and mammary gland tumor development in I/LnJ mice are controlled by a single locus.

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