The knockout mouse project.
Document Type
Article
Publication Date
2004
Keywords
Animals, Genetic-Research, Mice, Mice-Knockout, Phenotype, Research-Embryo-Creation
First Page
921
Last Page
924
JAX Source
Nat Genet 2004 Sep; 36(9):921-4.
Abstract
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.
Recommended Citation
Austin CP,
Battey JF,
Bucan M,
Collins FS,
Dove WF,
Eppig JT,
Nagy A,
Pollock JD,
Seed B,
Varmus H,
Vogt TF,
Woychik RP,
et al .
The knockout mouse project. Nat Genet 2004 Sep; 36(9):921-4.