Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Document Type
Article
Publication Date
2001
Keywords
Animals, Diabetes-Mellitus-Type-2, Female, Insulin, Insulin-Resistance, Male, Mice-Knockout, Mice-Transgenic, Phenotype, RNA, Receptor-Insulin, Signal-Transduction, Tissue-Distribution
First Page
1205
Last Page
1213
JAX Source
J Clin Invest 2001 Oct; 108(8):1205-13.
Abstract
Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of uncoupling protein-1 and -2. In parallel, these mice develop an insulin-secretion defect resulting in a progressive glucose intolerance, without insulin resistance. This model provides direct evidence for not only a role for the insulin receptors in brown fat adipogenesis, the data also suggest a novel role of brown adipose tissue in the regulation of insulin secretion and glucose homeostasis.
Recommended Citation
Guerra C,
Navarro P,
Valverde AM,
Arribas M,
Bruning J,
Kozak LP,
Kahn CR,
Benito M.
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J Clin Invest 2001 Oct; 108(8):1205-13.