Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration.
Gene-Expression-Profiling, Humans, Mice-Inbred-C57BL, Mice-Knockout, Muscle-Skeletal, MyoD-Protein, Promoter-Regions-Genetic, Regeneration, Transcription-Factors
J Biol Chem 2002 Aug; 277(33):30091-101.
Temporal expression profiling was utilized to define transcriptional regulatory pathways in vivo in a mouse muscle regeneration model. Potential downstream targets of MyoD were identified by temporal expression, promoter data base mining, and gel shift assays; Slug and calpain 6 were identified as novel MyoD targets. Slug, a member of the snail/slug family of zinc finger transcriptional repressors critical for mesoderm/ectoderm development, was further shown to be a downstream target by using promoter/reporter constructs and demonstration of defective muscle regeneration in Slug null mice.
Zhao, P; Iezzi, S; Carver, E; Dressman, D; Gridley, T; Sartorelli, V; and Hoffman, E P., "Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration." (2002). Faculty Research 2000 - 2009. 924.