Kick it up a Notch: NOTCH1 activation in T-ALL.
Document Type
Article
Publication Date
2004
Keywords
Humans, Leukemia-T-Cell-Acute, Mutation, Receptors-Cell-Surface, Signal-Transduction, Transcription-Factors
First Page
431
Last Page
432
JAX Source
Cancer Cell 2004 Nov; 6(5):431-2.
Abstract
While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL.
Recommended Citation
Gridley T.
Kick it up a Notch: NOTCH1 activation in T-ALL. Cancer Cell 2004 Nov; 6(5):431-2.
COinS