Kick it up a Notch: NOTCH1 activation in T-ALL.
Humans, Leukemia-T-Cell-Acute, Mutation, Receptors-Cell-Surface, Signal-Transduction, Transcription-Factors
Cancer Cell 2004 Nov; 6(5):431-2.
While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL.
Gridley, T, "Kick it up a Notch: NOTCH1 activation in T-ALL." (2004). Faculty Research 2000 - 2009. 974.