Mammalian recombination hot spots: properties, control and evolution.
Nat Rev Genet 2010 Mar; 11(3):221-33.
Recombination, together with mutation, generates the raw material of evolution, is essential for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to construct genome-scale, high-resolution recombination maps and new molecular techniques for analysing recombination products have substantially furthered our understanding of this important biological phenomenon in humans and mice: from describing the properties of recombination hot spots in male and female meiosis to the recombination landscape along chromosomes. This progress has been accompanied by the identification of trans-acting systems that regulate the location and relative activity of individual hot spots.
Mammalian recombination hot spots: properties, control and evolution. Nat Rev Genet 2010 Mar; 11(3):221-33.