Title

Humanized mice for the study of type 1 and type 2 diabetes.

Document Type

Article

Publication Date

2011

Keywords

Diabetes-Mellitus-Type-1, Diabetes-Mellitus-Type-2, Disease-Models-Animal, HLA-Antigens, Hematopoietic-Stem-Cell-Transplantation, Humans, Hyperglycemia, Interleukin-Receptor-Common-gamma-Subunit, Islets-of-Langerhans-Transplantation, Mice-Inbred-NOD, Mice-SCID, Mice-Transgenic, Transplantation-Heterologous

JAX Source

Ann N Y Acad Sci 2011 Dec; 1245:55-8.

Abstract

The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.

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