Title

Humanized mice as a preclinical tool for infectious disease and biomedical research.

Document Type

Article

Publication Date

2011

Keywords

Communicable-Diseases, Disease-Models-Animal, HLA-Antigens, Humans, Interleukin-Receptor-Common-gamma-Subunit, Mice-Inbred-NOD, Mice-SCID, Mice-Transgenic, Models-Immunological, Neoplasms, Receptors-Immunologic, Regenerative-Medicine, T-Lymphocytes, Transplantation-Chimera

JAX Source

Ann N Y Acad Sci 2011 Dec; 1245:50-4.

Abstract

Immunodeficient mice bearing an IL2rgamma(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

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