Humanized mice as a preclinical tool for infectious disease and biomedical research.
Communicable-Diseases, Disease-Models-Animal, HLA-Antigens, Humans, Interleukin-Receptor-Common-gamma-Subunit, Mice-Inbred-NOD, Mice-SCID, Mice-Transgenic, Models-Immunological, Neoplasms, Receptors-Immunologic, Regenerative-Medicine, T-Lymphocytes, Transplantation-Chimera
Ann N Y Acad Sci 2011 Dec; 1245:50-4.
Immunodeficient mice bearing an IL2rgamma(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.
Shultz, L D.; Brehm, M A.; Bavari, S; and Greiner, D L., "Humanized mice as a preclinical tool for infectious disease and biomedical research." (2011). Faculty Research 2011. 133.