MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.
Document Type
Article
Publication Date
11-1-2011
Keywords
Animals, B-Lymphocyte Subsets, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, H-2 Antigens, Histocompatibility Antigens Class I, Killer Cells, Natural, Lupus Erythematosus, Systemic, Lymphoma, B-Cell, Mice, Mice, Inbred Strains, Moloney murine leukemia virus, beta 2-Microglobulin
JAX Source
J Immunol 2011 Nov 1; 187(9):4695-704.
PMID
21964024
Volume
187
Issue
9
First Page
4695
Last Page
4704
ISSN
1550-6606
Abstract
Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8(+) T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases.
Recommended Citation
McPhee C,
Sproule T,
Shin D,
Bubier J,
Schott W,
Steinbuck M,
Avenesyan L,
Morse H,
Roopenian D.
MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 2011 Nov 1; 187(9):4695-704.