Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic Acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Randy Strong
Richard A Miller
Clinton M Astle
Joseph A Baur
Rafael de Cabo
Elizabeth Fernandez
Wen Guo
Martin Javors
James L Kirkland
James F Nelson
David A Sinclair
Bruce Teter
David Williams
Nurulain Zaveri
Nancy L Nadon
David E Harrison


The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.