Impact of the Environment on the Skeleton: Is it Modulated by Genetic Factors?
Document Type
Article
Publication Date
9-2013
JAX Location
Reprint Collection
JAX Source
Curr Osteoporos Rep 2013 Sep; 11(3):219-28.
Volume
11
Issue
3
First Page
219
Last Page
228
ISSN
1544-2241
PMID
23846556
Abstract
The etiology of skeletal disease is driven by genetic and environmental factors. Genome-wide association studies (GWAS) of osteoporotic phenotypes have identified novel candidate genes, but have only uncovered a small proportion of the trait variance explained. This "missing heritability" is caused by several factors, including the failure to consider gene-by-environmental (G*E) interactions. Some G*E interactions have been investigated, but new approaches to integrate environmental data into genomic studies are needed. Advances in genotyping and meta-analysis techniques now allow combining genotype data from multiple studies, but the measurement of key environmental factors in large human cohorts still lags behind, as do the statistical tools needed to incorporate these measures in genome-wide association meta-studies. This review focuses on discussing ways to enhance G*E interaction studies in humans and how the use of rodent models can inform genetic studies. Understanding G*E interactions will provide opportunities to effectively target intervention strategies for individualized therapy. Curr Osteoporos Rep 2013 Sep; 11(3):219-28.
Recommended Citation
Ackert-Bicknell CL,
Karasik D.
Impact of the Environment on the Skeleton: Is it Modulated by Genetic Factors? Curr Osteoporos Rep 2013 Sep; 11(3):219-28.