Mouse models for studies of retinal degeneration and diseases.
Animals, Disease Models, Animal, Electroretinography, Fluorescein Angiography, Fundus Oculi, Genetic Testing, Humans, Mice, Ophthalmoscopy, Retina, Retinal Degeneration
Methods Mol Biol 2013; 935:27-39.
Mouse models, with their well-developed genetics and similarity to human physiology and anatomy, serve as powerful tools with which to investigate the etiology of human retinal degeneration. Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function. Here, I describe the tools used in the discoveries of many retinal degeneration models, including indirect ophthalmoscopy (to look at the fundus appearance), fundus photography and fluorescein angiography (to document the fundus appearance), electroretinography (to check retinal function), as well as the heritability test (for genetic characterization). Methods Mol Biol 2013; 935:27-39.
Chang, Bo, "Mouse models for studies of retinal degeneration and diseases." (2013). Faculty Research 2013. 7.