Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines.

Authors

Chun I. Yu, The Jackson LaboratoryFollow
Christian Becker
Patrick Metang, The Jackson LaboratoryFollow
Florentina Marches, The Jackson LaboratoryFollow
Yuanyuan Wang
Hori Toshiyuki
Jacques Banchereau, The Jackson LaboratoryFollow
Miriam Merad
A Karolina Palucka, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

11-1-2014

JAX Source

J Immunol 2014 Nov 1; 193(9):4335-43.

Volume

193

Issue

9

First Page

4335

Last Page

4343

ISSN

1550-6606

PMID

25246496

Abstract

Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses. J Immunol 2014 Nov 1; 193(9):4335-43.

Recommended Citation

Yu CI, Becker C, Metang P, Marches F, Wang Y, Toshiyuki H, Banchereau J, Merad M, Palucka A. Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines. J Immunol 2014 Nov 1; 193(9):4335-43.