Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines.
J Immunol 2014 Nov 1; 193(9):4335-43.
Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses. J Immunol 2014 Nov 1; 193(9):4335-43.
Yu, Chun I.; Becker, Christian; Metang, Patrick; Marches, Florentina; Wang, Yuanyuan; Toshiyuki, Hori; Banchereau, Jacques; Merad, Miriam; and Palucka, A Karolina, "Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines." (2014). Faculty Research 2014. 170.