Human plasma cells express granzyme B.
Document Type
Article
Publication Date
1-2014
JAX Source
Eur J Immunol 2014 Jan; 44(1):275-84.
Volume
44
Issue
1
First Page
275
Last Page
284
ISSN
1521-4141
PMID
24114594
Abstract
While studying the plasma cell (PC) compartment in human tonsils, we identified that immunoglobulin kappa or lambda chain-expressing PCs are the main cells expressing granzyme B (GrzB). In vitro studies revealed that activated B cells differentiated into GrzB-expressing PCs when co-cultured with macrophages and follicular helper T cells. This effect could be reproduced on combined stimulation of IL-15 (produced by macrophages) and IL-21 (produced by T follicular helper cells) in a STAT3-dependent manner. Whereas IL-21 triggers the transcription of mRNA of GrzB, IL-15 synergizes the translation of GrzB proteins. The precise role of GrzB in PC biology remains to be understood and studies in mice will not help as their PCs do not express GrzB. Eur J Immunol 2014 Jan; 44(1):275-84.
Recommended Citation
Xu W,
Narayanan P,
Kang N,
Clayton S,
Ohne Y,
Shi P,
Herve M,
Balderas R,
Picard C,
Casanova J,
Gorvel J,
Oh S,
Pascual V,
Banchereau J.
Human plasma cells express granzyme B. Eur J Immunol 2014 Jan; 44(1):275-84.