Genetically engineered humanized mouse models for preclinical antibody studies.
BioDrugs 2014 Apr; 28(2):171-80.
The use of genetic engineering has vastly improved our capabilities to create animal models relevant in preclinical research. With the recent advances in gene-editing technologies, it is now possible to very rapidly create highly tunable mouse models as needs arise. Here, we provide an overview of genetic engineering methods, as well as the development of humanized neonatal Fc receptor (FcRn) models and their use for monoclonal antibody in vivo studies.
Proetzel, Gabriele; Wiles, Michael V.; and Roopenian, Derry C., "Genetically engineered humanized mouse models for preclinical antibody studies." (2014). Faculty Research 2014. 80.