Title

Cross-organism analysis using InterMine.

Document Type

Article

Publication Date

8-1-2015

Keywords

Animals, Computational Biology, Databases, Factual, Databases, Genetic, Genomics, Humans, Internet, Software, Systems Integration, User-Computer Interface

JAX Source

Genesis 2015 Aug; 53(8):547-60.

PMID

26097192

DOI

https://doi.org/10.1002/dvg.22869

Abstract

InterMine is a data integration warehouse and analysis software system developed for large and complex biological data sets. Designed for integrative analysis, it can be accessed through a user-friendly web interface. For bioinformaticians, extensive web services as well as programming interfaces for most common scripting languages support access to all features. The web interface includes a useful identifier look-up system, and both simple and sophisticated search options. Interactive results tables enable exploration, and data can be filtered, summarized, and browsed. A set of graphical analysis tools provide a rich environment for data exploration including statistical enrichment of sets of genes or other entities. InterMine databases have been developed for the major model organisms, budding yeast, nematode worm, fruit fly, zebrafish, mouse, and rat together with a newly developed human database. Here, we describe how this has facilitated interoperation and development of cross-organism analysis tools and reports. InterMine as a data exploration and analysis tool is also described. All the InterMine-based systems described in this article are resources freely available to the scientific community.

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