Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.
Document Type
Article
Publication Date
2016
JAX Location
Reprint Collection
JAX Source
Methods Mol Biol 2016; 1438:104-14
Volume
1438
First Page
103
Last Page
114
ISSN
1940-6029
PMID
27150086
Abstract
Therapeutic monoclonal antibodies are widely recognized to be a most promising means to treat an increasing number of human diseases, including cancers and autoimmunity. To a large extent, the efficacy of monoclonal antibody treatment is because IgG antibodies have greatly extended persistence in vivo. However, conventional rodent models do not mirror human antibody pharmacokinetics. The key molecule responsible for the extended persistence antibodies is the major histocompatibility complex class I family Fc receptor, FcRn. We describe human FcRn transgenic mouse models and how they can be exploited productively for the preclinical pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 2016; 1438:104-14
Recommended Citation
Roopenian DC,
Christianson GJ,
Proetzel G,
Sproule TJ.
Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies. Methods Mol Biol 2016; 1438:104-14