Title
Revisiting Cardiac Cellular Composition.
Document Type
Article
Publication Date
2-5-2016
JAX Source
Circ Res 2016 Feb 5; 118(3):400-9
PMID
26635390
Abstract
RATIONALE: Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration.
OBJECTIVE: To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and fibroblasts in the mouse and human heart.
METHODS AND RESULTS: Using a combination of genetic tools and cellular markers, we examined the occurrence of the most prominent cell types in the adult mouse heart. Immunohistochemistry revealed that endothelial cells constitute >60%, hematopoietic-derived cells 5% to 10%, and fibroblasts
CONCLUSIONS: This new perspective on the abundance of different cell types in the heart demonstrates that fibroblasts comprise a relatively minor population. By contrast, endothelial cells constitute the majority of noncardiomyocytes and are likely to play a greater role in physiological function and response to injury than previously appreciated.
Circ Res 2016 Feb 5; 118(3):400-9
Recommended Citation
Pinto, Alexander R; Ilinykh, Alexei; Ivey, Malina J; Kuwabara, Jill T; D'Antoni, Michelle L; Debuque, Ryan; Chandran, Anjana; Wang, Lina; Arora, Komal; Rosenthal, Nadia A; and Tallquist, Michelle D, "Revisiting Cardiac Cellular Composition." (2016). Faculty Research 2016. 117.
https://mouseion.jax.org/stfb2016/117