Title
MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs).
Document Type
Article
Publication Date
2016
JAX Source
Exp Mol Pathol 2016 Feb; 100(1):212-219
Volume
100
Issue
1
First Page
212
Last Page
219
ISSN
1096-0945
PMID
26778691
Abstract
Infection by mouse papillomavirus (PV), MmuPV1, of T cell-deficient, B6.Cg-Foxn1(nu)/J nude mice revealed that four, distinct squamous papilloma phenotypes developed simultaneously after infection of experimental mice. Papillomas appeared on the muzzle, vagina, and tail at or about day 42days post-inoculation. The dorsal skin developed papillomas and hair follicle tumors (trichoblastomas) as early as 26days after infection. Passive transfer of hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs) to T cell-deficient strains of mice prevented infection by virions of experimental mice. This study provides further evidence that T cell deficiency is critical for tumor formation by MmuPV1 infection. Exp Mol Pathol 2016 Feb; 100(1):212-219
Recommended Citation
Joh J,
Ghim S,
Chilton P,
Sundberg J,
Park J,
Wilcher S,
Proctor M,
Bennett Jenson A.
MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs). Exp Mol Pathol 2016 Feb; 100(1):212-219