Title
MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs).
Document Type
Article
Publication Date
2016
JAX Source
Exp Mol Pathol 2016 Feb; 100(1):212-219
PMID
26778691
Abstract
Infection by mouse papillomavirus (PV), MmuPV1, of T cell-deficient, B6.Cg-Foxn1(nu)/J nude mice revealed that four, distinct squamous papilloma phenotypes developed simultaneously after infection of experimental mice. Papillomas appeared on the muzzle, vagina, and tail at or about day 42days post-inoculation. The dorsal skin developed papillomas and hair follicle tumors (trichoblastomas) as early as 26days after infection. Passive transfer of hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs) to T cell-deficient strains of mice prevented infection by virions of experimental mice. This study provides further evidence that T cell deficiency is critical for tumor formation by MmuPV1 infection. Exp Mol Pathol 2016 Feb; 100(1):212-219
Recommended Citation
Joh, Joongho; Ghim, Shin-Je; Chilton, Paula M; Sundberg, John P; Park, Jino; Wilcher, Sarah A; Proctor, Mary L; and Bennett Jenson, A, "MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)." (2016). Faculty Research 2016. 19.
https://mouseion.jax.org/stfb2016/19