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Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses. NSG™* and NSG™-SGM3* mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Here, we provide evidence that NSG and NSG-SGM3 mice engrafted with hematopoietic stem cells (collectively referred to here as “humanized NSG mice”) can support the growth of allogeneic human tumors. The human tumors respond to standard-of-care chemotherapeutics, targeted therapies, and to immune check-point inhibitors clinically proven to initiate cytotoxic activity towards the tumor. Tumor-bearing, humanized NSG mice (the Onco- Hu™* mouse offered exclusively from The Jackson Laboratory) are a new and valuable preclinical testing platform for immuno-oncology.