Title

Application of Mouse Models to Research in Hearing and Balance.

Document Type

Article

Publication Date

12-2016

JAX Location

Reprint Collection

JAX Source

J Assoc Res Otolaryngol 2016 Dec; 17(6):493-523.

Volume

17

Issue

6

First Page

493

Last Page

523

ISSN

1438-7573

PMID

27752925

Abstract

Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models. J Assoc Res Otolaryngol 2016 Dec; 17(6):493-523.

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