The Mediator of Hematopoietic Stem Cell Homeostasis.

Sneha Borikar, The Jackson Laboratory
Jennifer J. Trowbridge, The Jackson Laboratory


Mechanisms establishing and maintaining promoter-enhancer interactions in hematopoietic stem cells (HSCs) to maintain stem cell identity are not fully understood. In this issue of Cell Stem Cell, Aranda-Orgilles et al. (2016) describe a role for a member of the Mediator complex in maintaining HSC-specific enhancers and hematopoietic homeostasis. Cell Stem Cell 2016 Dec 1; 19(6):677-678.