Open chromatin profiling as a novel strategy for identifying cancer cell of origin.
Mol Cell Oncol 2016 Sep 30; 3(6):e1236770
CA184851, CA034196, HD007065
Tumor cell of origin is an important prognostic measure but is challenging to assess. We recently demonstrated in acute myeloid leukemia (AML) that the chromatin landscape serves as a biomarker of transformed cell of origin. Thus, open chromatin loci offer important prognostic information as well as targets for development of novel therapies in cancer treatment. Mol Cell Oncol 2016 Sep 30; 3(6):e1236770
Young, Kira and Trowbridge, Jennifer J., "Open chromatin profiling as a novel strategy for identifying cancer cell of origin." (2016). Faculty Research 2016. 264.