Title

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.

Document Type

Article

Publication Date

12-2017

JAX Source

Nat Genet 2017 Dec 49(12):1714-1721

PMID

29083405

DOI

https://doi.org/10.1038/ng.3959

Abstract

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders. Nat Genet 2017 Dec 49(12):1714-1721.