Humanized Mouse Models of Clinical Disease.
Document Type
Article
Publication Date
1-24-2017
JAX Source
Annu Rev Pathol 2017; 12:187-215
Volume
12
First Page
187
Last Page
215
ISSN
1553-4014
PMID
27959627
DOI
https://doi.org/10.1146/annurev-pathol-052016-100332
Grant
CA034196, DK104218, OD018259, Maine Cancer Foundation, Sackler Foundation
Abstract
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, investigators have been able to engraft murine recipients with human hematopoietic stem cells that develop into functional human immune systems. These mice can also be engrafted with human tissues such as islets, liver, skin, and most solid and hematologic cancers. Humanized mice are permitting significant progress in studies of human infectious disease, cancer, regenerative medicine, graft-versus-host disease, allergies, and immunity. Ultimately, use of humanized mice may lead to the implementation of truly personalized medicine in the clinic. This review discusses recent progress in the development and use of humanized mice and highlights their utility for the study of human diseases. Annu Rev Pathol 2017; 12:187-215.
Recommended Citation
Walsh N,
Kenney L,
Jangalwe S,
Aryee K,
Greiner D,
Brehm M,
Shultz LD.
Humanized Mouse Models of Clinical Disease. Annu Rev Pathol 2017; 12:187-215