Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.
Document Type
Article
Publication Date
3-1-2017
JAX Source
Dis Model Mech 2017 Mar 1; 10(3):259-270.
Volume
10
Issue
3
First Page
259
Last Page
270
ISSN
1754-8411
PMID
28250051
Grant
Jackson Laboratory Endowment
Abstract
Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity. Dis Model Mech 2017 Mar 1; 10(3):259-270.
Recommended Citation
Hasham MG,
Baxan N,
Stuckey D,
Branca J,
Perkins B,
Dent O,
Duffy T,
Hameed T,
Stella S,
Bellahcene M,
Schneider M,
Harding S,
Rosenthal N,
Sattler S.
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease. Dis Model Mech 2017 Mar 1; 10(3):259-270.